Lactocepin secreted by lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines
Cell Host & Microbe, 05/10/2012
von Schillde MA et al. – A human Lactobacillus casei isolate was also found to encode lactocepin and degrade IP–10. L. casei feeding studies in a murine colitis model revealed that a prtP–disruption mutant was significantly less potent in reducing IP–10 levels, T cell infiltration and inflammation in cecal tissue compared to the isogenic wild–type strain. Thus, lactocepin–based therapies may be effective treatments for chemokine–mediated diseases like IBD.
