Clinical audit of antiphospholipid antibody testing in tertiary practice: towards improved relevance in thrombophilia investigations

Internal Medicine Journal, 04/20/2012

The authors determined a wide variety of clinical ordering background for antiphospholipid antibodies (aPL) at a tertiary level institution, with an overall low rate of aPL positivity among a hospital population of predominantly obstetric or thrombophilic patients. That no positive obstetric aPL cases were identified suggests local clinical ordering guidelines may need review, as also potentially practised at other institutions. THe authors also observed a moderate rate of coincidence of aCL and LA, in agreement with guidelines indicating that multiple tests are required to identify antiphospholipid syndrome (APS).

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