Association of chemokine CXCL12-3'G801A polymorphism with systemic lupus erythematosus in a Han Chinese population

Lupus, 04/26/2012

The results suggest that polymorphism in CXCL12–3'G801A might be a genetic risk factor for developing systemic lupus erythematosus (SLE). The association of G/G homozygote with nephritis and skin damage developed in SLE patients might be due to its effects upon the production of auto–antibodies and CXCL12 protein.

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