Diabetes mellitus and the incidence and mortality of colorectal cancer: A meta-analysis of twenty four cohort studies
Colorectal Disease,  Clinical Article

Luo W et al. – The meta–analysis suggests diabetic individuals have a significant increase in risk of developing colorectal cancer.

  • MEDLINE and EMBASE were searched for articles published before July 2010.
  • Cohort studies that evaluated DM and CRC incidence and mortality were included.
  • The initial search identified 1887 titles, of which 24 articles met the inclusion criteria.
  • The authors defined the relative risk (RR) as the metric of choice, with 95% confidence intervals (CIs) were calculated with a random-effects model.

  • There was an increase in the RR of developing colorectal cancer in persons with diabetes compared with those without diabetes (RR 1.28 [95%CI 1.19 - 1.39]), without heterogeneity between studies (Pheterogeneity = .13).
  • The association between duration of DM and CRC incidence was stronger in 11–15 yr group (RR 1.51 [95%CI 1.12 - 2.03]) than in < 10 yr (RR 1.05 [95%CI 0.90 - 1.22]) and >15 yr group (RR 1.25 [95%CI 0.80 - 1.94]), and there was significant heterogeneity among subgroups (Pheterogeneity = .01).
  • In studies reporting standardized incidence ratios (SIR), there was an increased incidence of CRC with DM (RR 1.27 [95%CI 1.14 - 1.42] Pheterogeneity = .09); and the association was stronger among males (RR 1.47 [95%CI 1.15 - 1.86]) than females (RR 1.08 [95%CI 1.00 - 1.17]), there was significant heterogeneity among gender (Pheterogeneity = .01).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More