mdlinx mdlinx
Latest (347) Full Text Articles (9654) Focus on Depression Article Summary

Diabetes mellitus and the incidence and mortality of colorectal cancer: A meta-analysis of twenty four cohort studies
Colorectal Disease,  Clinical Article

Luo W et al. – The meta–analysis suggests diabetic individuals have a significant increase in risk of developing colorectal cancer.

  • MEDLINE and EMBASE were searched for articles published before July 2010.
  • Cohort studies that evaluated DM and CRC incidence and mortality were included.
  • The initial search identified 1887 titles, of which 24 articles met the inclusion criteria.
  • The authors defined the relative risk (RR) as the metric of choice, with 95% confidence intervals (CIs) were calculated with a random-effects model.

  • There was an increase in the RR of developing colorectal cancer in persons with diabetes compared with those without diabetes (RR 1.28 [95%CI 1.19 - 1.39]), without heterogeneity between studies (Pheterogeneity = .13).
  • The association between duration of DM and CRC incidence was stronger in 11–15 yr group (RR 1.51 [95%CI 1.12 - 2.03]) than in < 10 yr (RR 1.05 [95%CI 0.90 - 1.22]) and >15 yr group (RR 1.25 [95%CI 0.80 - 1.94]), and there was significant heterogeneity among subgroups (Pheterogeneity = .01).
  • In studies reporting standardized incidence ratios (SIR), there was an increased incidence of CRC with DM (RR 1.27 [95%CI 1.14 - 1.42] Pheterogeneity = .09); and the association was stronger among males (RR 1.47 [95%CI 1.15 - 1.86]) than females (RR 1.08 [95%CI 1.00 - 1.17]), there was significant heterogeneity among gender (Pheterogeneity = .01).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Internal Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicinemore

Other Topics in Internal Medicine

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool


Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More