ABO blood group, hepatitis B viral infection and risk of pancreatic cancer
International Journal of Cancer,  Clinical Article

Wang DS et al. – The authors reported an association between A blood type, infection with hepatitis B viral (HBV) and pancreatic cancer risk. Moreover, they found a synergism between A blood type and HBV infection in the development of pancreatic cancer.

Methods
  • A total of 645 patients with pancreatic adenocarcinoma and 711 age- and sex-matched individuals who had nonmalignant diseases treated at the Sun Yat-sen University Cancer Center in China were retrospectively analyzed.
  • Blood samples were tested for ABO blood type and hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B e antigen (HBeAg), hepatitis B e antibody (anti-HBe) and hepatitis B core antibody (anti-HBc).
  • Multivariable unconditional logistic regression analysis was used to estimate adjusted odds ratios [AORs] and 95% confidence interval [CI].

Results
  • Multivariable analysis with adjustment for risk factors showed that A blood type, HBsAg-positive/anti-HBc-positive, anti-HBs-positive/anti-HBc-positive were significantly associated with pancreatic cancer.
  • The estimated AORs (95% CI) were as follows: A blood type, 1.425 (1.071-1.894), HBsAg-positive/anti-HBc-positive, 1.610 (1.125-2.304), anti-HBs-positive/anti-HBc-positive, 1.526 (1.159-2.011).
  • The effect of A blood type significantly modified the risk of pancreatic cancer among subjects with anti-HBc-positive (AORs=1.882, 95% CI, 1.284-2.760).

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