The contrasting age-incidence patterns of bone tumours in teenagers and young adults: Implications for aetiology
International Journal of Cancer, 04/26/2012
Arora RS et al. – The proportions of Ewing sarcomas occurring in respective bones were consistent with those of the adult skeleton by weight. In osteosarcoma tumours of long bones of lower limb were markedly over–represented in the adolescent peak, being six times more than at any other site. Variation in incidence patterns with age and site suggests pubertal bone growth to be a key factor in osteosarcoma while different biological pathways could be relevant for Ewing sarcoma.