Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial
Diseases of the Esophagus, 05/07/2012
Manabe N et al. – Omeprazole combined with sodium alginate was better than omeprazole alone in Japanese patients with Nonerosive reflux disease (NERD).Methods
- Patients who had experienced heartburn on at least 2 days per week during the 1-month period before entering the study and had no endoscopic mucosal breaks (grade M or N according to Hoshihara's modification of the Los Angeles classification) were randomized to one of two treatments for 4 weeks: omeprazole (20 mg once daily) plus sodium alginate (30 mL four times a day) (group A) or omeprazole (20 mg once daily) alone (group B).
- Eighty-seven patients were enrolled, and 76 patients were randomly assigned to group A (n= 36) or group B (n= 40).
- Complete resolution of heartburn for at least 7 consecutive days by the end of treatment was significantly more common in group A (56.7%) than in group B (25.7%).
- One patient from group A had mild drug-related diarrhea that was not clinically serious.