Wang H et al. – The lipid modulating effects of vitamin D supplementation should be further investigated though large–scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.Methods
- Authors conducted a meta–analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids.
- A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids.
- The mean change in total cholesterol (TC), low–density lipoprotein cholesterol (LDL–C), high–density lipoprotein cholesterol (HDL–C) and triglycerides (TG) from baseline was treated as a continuous variable.
- In all, 12 clinical trials consisting of 1346 participants were included in the analysis.
- The pooled estimate of effect for vitamin D supplementation on LDL–C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl).
- No statistically significant effects for vitamin D supplementation were observed for TC, HDL–C and TG (differences in means were 1.52 mg/dl (1.42 to 4.46 mg/dl), –0.14 mg/dl (0.99 to 0.71 mg/dl) and 1.92 mg/dl (7.72 to 3.88 mg/dl) respectively).