Antimicrobial peptides in the pathogenesis of psoriasis
The Journal of Dermatology, 03/21/2012
Morizane S et al. – In psoriatic lesions, many antimicrobial peptides and proteins (AMPs) are highly expressed, and especially the associations between psoriasis and cathelicidin, β–defensins or S100 proteins have been well studied. Among them, a cathelicidin peptide, LL–37, has been highlighted as a modulator of psoriasis development in recent years. AMPs had been thought to worsen psoriatic lesions but recent evidence has also suggested the possibility that the induction of AMPs expression might improve aspects of the disease.