Changes in BMI, Duration of Overweight and Obesity, and Glucose Metabolism: 45 years of follow-up of a birth cohort Full Text
Diabetes Care, 08/11/2011
Power C et al. – Excessive BMI gain across the life span and earlier onset of overweight/obesity are associated with impaired glucose metabolism, in part through attained adult BMI.Methods
- Participants in the 1958 British birth cohort with child to adult BMI and glycosylated hemoglobin (HbA1c) at 45 years (n = 7,855).
- Prevalence of type 2 diabetes or HbA1c ≥7 was 2%. BMI gains in child- and adulthood were associated with higher HbA1c: for every SD of 5-year BMI increase from 0 to 7 years, there was a 75% (95% CI 1.42–2.16) increased risk of HbA1c ≥7, increasing to a 4.7-fold (3.12–7.00) risk for the interval 23–33 years.
- Associations for BMI gain in adulthood were related to attained BMI but were independent for the longer period birth (or 7 years) to 45 years.
- Duration of obesity was also associated with HbA1c; compared with the never obese, those with childhood onset had a 23.9-fold risk (13.5–42.1) of HbA1c ≥7%; odds ratios were 16.0 (10.6–24.2) and 2.99 (1.77–5.03), respectively, for young and midadulthood onset.
- Similar trends by onset age were found in mean HbA1c levels and for onset of overweight.
- Those with the earliest age of onset had higher BMI and waist circumference at 45 years, which markedly explained the associations for onset age and HbA1c.