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Does Long-Term Aspirin Use Have Any Effect On Helicobacter pylori Eradication
The American Journal of the Medical Sciences, 06/24/2011
Gokturk HS et al. – The data suggest that H pylori eradication rate with standard triple eradication regimen is significantly higher among long–term aspirin users than in controls.
Methods- The study population consisted of 77 aspirin using patients with dyspeptic symptoms and 79 age– and sex–matched dyspeptic patients without aspirin use as a control group.
- Both the study group and control patients were given lansoprazole (30 mg twice a day), clarithromycin (500 mg twice a day) and amoxicillin (1 g twice a day) (LCA) for 14 days as the eradication regimen.
- Patients on the study group were allowed to take aspirin during the eradication regimen (LCAAsp).
- Eradication was defined as the absence of H pylori as assessed with the 13C–urea breath test and H pylori stool antigen test 8 weeks after the end of the antimicrobial therapy.
- The H pylori eradication rate in the LCAAsp group was 64/77 [83%, 95% confidence interval (CI): 79%–94%] with intention–to–treat (ITT) analysis and 64/75 (85%, 95% CI: 82%–96%) with per protocol (PP) analysis, and the H pylori eradication rate in the LCA group was 42/79 (53%, 95% CI: 43%–65%) with ITT analysis and 42/75 (56%, 95% CI: 46%–68%) with PP analysis.
- The difference between the groups both with ITT analysis and with PP analysis was statistically significant (P < 0.05).
