A new promising drug in the treatment of osteoporosis Full Text
Journal of Orthopaedics, 06/23/2011
Bhuvaneshwari G et al. – Denosumab is a newer drug with different mode of action. It effectively controls bone loss in Osteoporosis. The present review considers recent knowledge of Denosumab, mechanism of action, therapeutic uses and adverse drug reactions.
- Osteoporosis is a clinical condition characterized by abnormal loss of bone predisposing to fractures.
- Plasma calcium levels decreased bone calcium is mobilized by osteoclasts bone resorption activity which is stimulated by para thyroid hormone and vitamin D
- Currently calcium dietary supplements and vitamin D, sodium fluoride, calcitonin, bisphosphonates, female sex hormones were used in osteoporotic therapy