Vitamin D Deficiency in Patients With Inflammatory Bowel Disease- Association With Disease Activity and Quality of Life
Journal of Parenteral and Enteral Nutrition, 05/10/2011
Ulitsky A et al. – Vitamin D deficiency is common in inflammatory bowel disease (IBD) and is independently associated with lower health–related quality of life(HRQOL) and greater disease activity in Crohn’s disease. There is a need for prospective studies to assess this correlation and examine the impact of vitamin D supplementation on disease course.Methods
- Retrospective cohort study was conducted.
- Harvey-Bradshaw index and ulcerative colitis disease activity index were used to assess disease activity.
- Short Inflammatory Bowel Disease Questionnaire scores were used to assess HRQOL.
- Multivariate logistic regression was used to identify independent predictors of vitamin D deficiency and its association with disease activity and HRQOL.
- tudy included 504 IBD patients (403 Crohn’s disease [CD] and 101 ulcerative colitis [UC]) who had a mean disease duration of 15.5 years in CD patients and 10.9 years in UC patients; 49.8% were vitamin D deficient, with 10.9% having severe deficiency.
- Vitamin D deficiency was associated with older age (P=.004) and older age at diagnosis (P=.03).
- Vitamin D deficiency was associated with lower HRQOL (regression coefficient -2.21, 95% confidence interval [CI], -4.10 to -0.33) in CD but not UC (regression coefficient 0.41, 95% CI, -2.91 to 3.73).
- Vitamin D deficiency was also associated with increased disease activity in CD (regression coefficient 1.07, 95% CI, 0.43 to 1.71).