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Use of Aspirin and Other Nonsteroidal Antiinflammatory Medications in Relation to Prostate Cancer Risk
American Journal of Epidemiology, 08/06/2010
Salinas CA et al. – A significant 21% reduction in the risk of prostate cancer was observed among current users of aspirin compared with nonusers. Long–term use of aspirin and daily use of low–dose aspirin were also associated with decreased risk. There was no evidence that the association with aspirin use varied by disease aggressiveness, but there was effect modification with a genetic variant in prostaglandin–endoperoxide synthase 2 (PTGS2). Prostate cancer risk was not related to use of either nonaspirin NSAIDs or acetaminophen. These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research.