Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency

Atherosclerosis, 06/12/2012

Results showed that in CBS deficient patients with elevated levels of tHcy (median (total range): 33 (14–237)μmol/L), both ADMA and SDMA levels were normal. Moreover, tHcy and ADMA concentrations were not correlated (rs=0.017, p=0.94). These results favor the hypothesis that the negative vascular effects of HHcy have an ADMA–independent etiology.

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