Endothelial Dysfunction and Increased Carotid Intima-Media Thickness in the Patients with Slow Coronary Flow

Journal of Korean Medical Science, 06/08/2012

Yoon HJ et al. – Endothelial dysfunction may be an earlier vascular phenomenon than increased carotid intima–media thickness in the patients with slow coronary flow.


  • A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography.
  • Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method.


  • Group I was a control with normal coronary angiography (n = 41, 56.1 ± 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 ± 10.0 yr).
  • Diabetes was rare but dyslipidemia and family history were frequent in group II.
  • Heart rate was higher in group II than in group I.
  • White blood cells, especially monocytes and homocysteine were higher in group II.
  • The FMD was significantly lower in group II than in group I.
  • Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis.

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