p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis

Gastroenterology, 06/04/2012

p28GANK(Gankyrin) activates and maintains liver T–ICs in Hepatocellular carcinoma (HCC) by preventing degradation of Oct4. Inhibitors of p28GANK might therefore be developed to inactivate tumor–initiating cells (T–ICs)s and slow tumor progression.

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