Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT2A receptor-dependent pathway

Cardiovascular Pathology, 06/01/2012

Combined elevated stretch and 5–HT resulted in increased valve collagen biosynthesis, cell proliferation, and tissue stiffness. These responses were inhibited by a 5–HT2A antagonist. This strongly suggests that the 5–HT2A receptor subtype is sensitive to elevated stretch.

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