Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

Internal Medicine Journal, 05/30/2012

The quantitative meta–analysis showed that diabetes was a risk factor for incident dementia [including Alzheimer's disease (AD), vascular dementia (VD) and any dementia] and mild cognitive impairment (MCI).

Methods

  • This study examined the association of diabetes with the onset of dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI) by using a quantitative meta–analysis of longitudinal studies.
  • EMBASE and MEDLINE were searched for articles published up to December 2010.
  • All studies that examined the relationship between diabetes and the onset of dementia or MCI were included.
  • Pooled relative risks were calculated using fixed and random effects models.
  • Nineteen studies met the inclusion criteria for this meta–analysis, and 6184 subjects with diabetes and 38530 subjects without diabetes were included respectively.

Results

  • All subjects were without dementia or MCI at baseline.
  • The quantitative meta–analysis showed that subjects with diabetes had higher risk for AD (relative risk (RR):1.46, 95% confidence interval (CI): 1.20–1.77), VD (RR: 2.48, 95% CI: 2.08–2.96), any dementia (RR: 1.51, 95% CI: 1.31–1.74) and MCI (RR: 1.21, 95% CI: 1.02–1.45) than those without.
  • The quantitative meta–analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI.

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