Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogrens syndrome
Annals of Rheumatic Diseases, 05/11/2012
Newton JL et al. – Autonomic symptoms are common among patients with primary Sjögren's syndrome (PSS) and may contribute to the overall burden of symptoms and link with systemic disease activity.
Multicentre, prospective, cross–sectional study of a UK cohort of 317 patients with clinically well–characterised PSS.
Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS).
The data were compared with an age– and sex–matched cohort of 317 community controls.
The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis.
COMPASS scores were significantly higher in patients with PSS than in age– and sex–matched community controls (median (IQR) 35.5 (20.9–46.0) vs 14.8 (4.4–30.2), p<0.0001).
Nearly 55% of patients (vs 20% of community controls, p<0.0001) had a COMPASS score >32.5, a cut–off value indicative of autonomic dysfunction.
Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p<0.001) and disease activity measured using the EULAR Sjögren's Syndrome Disease Activity Index (β=0.13, p<0.009).
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