T cells in systemic sclerosis: a reappraisal

Rheumatology, 05/11/2012

The data implicate the role of T cells in systemic sclerosis (SSc) and suggest that Th2–polarized T cells and the fibrotic mediators subsequently released directly induce fibrosis. Targeting such cytokines may be therapeutic not only in SSc but more generally in diseases where fibrosis is directed by inflammatory signals.

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