Effect of intensive lipid lowering on cardiovascular outcome in patients with and without inflammatory joint disease
Arthritis & Rheumatism, 05/11/2012
Semb AG et al. – Patients with and without inflammatory joint disease had comparable lipid lowering effect and risk reduction of cardiovascular disease (CVD) after intensive treatment with statins. Methods Of the 18889 patients participating in these 2 trials, 199 had RA, 46 AS, and 35 PsA. Intensive lipid lowering regimens were with atorvastatin 80 mg, conventional/low regimens with atorvastatin 10 mg or simvastatin 20–40mg. Median follow–up was nearly 5 years. Lipid levels and changes were examined with analyses of covariance. Effect on CVD was examined by Cox regression analyses and heterogeneity tests were performed. Results
Patients with RA and AS had lower baseline cholesterol compared to non–IJD (LSMeans ± SE180.7± 2.3 and 176.5 ± 4.7 vs. 185.6 ± 0.2 mg/dL; p=0.03 and p=0.05, respectively). The lipid reduction by statins was comparable in patients with and without IJD, and reduced risk of CVD was overall 20% in both IJD and non–IJD.