Reconstitution of aged bone marrow with young cells repopulates cardiac-resident bone marrow–derived progenitor cells and prevents cardiac dysfunction after a myocardial infarction

European Heart Journal, 05/08/2012

Bone marrow reconstitution with young BM cells in aged recipients restored progenitors in both the BM and, most importantly, the myocardium. The number and function of cardiac–resident BM–derived progenitor cells in the aged myocardium prior to injury was the major determinant for successful recovery of cardiac function. The aged heart was rejuvenated with young BM cells.

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