Estradiol/Testosterone Imbalance: Impact on Coronary Heart Disease Risk Factors in Postmenopausal Women
Cardiology, 05/08/2012Dai W et al.
The balance of the serum E2/T ratio was broken in the women with coronary heart disease (CHD), and an imbalanced E2/T ratio showed a strong association with cardiovascular risk factors in postmenopausal women with CHD.
114 controls and 124 postmenopausal women with CHD were selected for this study.
Serum levels of estradiol, testosterone, aromatase, sex hormone–binding globulin (SHBG), lipid–lipoprotein profile and high–sensitivity C–reactive protein were determined.
Compared with the control, the E2/T ratio decreased from 5.35 ± 2.78 to 3.88 ± 2.51 (p < 0.0001).
Multiple linear regression analysis showed that the E2/T ratio was negatively associated with total cholesterol, low–density lipoprotein cholesterol (LDL–c) and the atherogenic index of plasma, but positively associated with high–density lipoprotein cholesterol (HDL–c) and HDL–c/LDL–c (for all, p < 0.0001).
Authors found that there was a negative correlation between the E2/T ratio and aromatase (r = –0.192, p = 0.032) and a positive correlation between aromatase and SHBG (r = 0.938).
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