Increased intratumoral IL-22-producing CD4+ T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival

Cancer Immunology, Immunotherapy, 05/04/2012

The data indicate that IL–22+CD4+ T cells and Th22 cells are likely important in establishing the tumor microenvironment for gastric cancer (GC); increased intratumoral IL–22+CD4+ T cells and Th22 cells are associated with tumor progression and predict poorer patient survival, suggesting that tumor–infiltrating IL–22+CD4+ T cells and Th22 cells may be suitable therapeutic targets in patients with GC.

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