Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis
Journal of Korean Medical Science, 04/13/2012
Hong YJ et al. – Virtual histology–intravascular ultrasound analysis demonstrates that anemia at the time of clinical presentation is associated with vulnerable plaque component in patients with acute coronary syndrome.
The authors compared VH–IVUS findings between anemia group (171 patients, 260 lesions) and non–anemia group (569 patients, 881 lesions).
Anemia group had greater % necrotic core (NC) volume (21% ± 9% vs 19% ± 9%, P = 0.001) compared with non–anemia group.
Hemoglobin level correlated negatively with absolute NC volume (r = –0.235, P < 0.001) and %NC volume (r = –0.209, P < 0.001).
Independent predictors of TCFA by multivariate analysis were diabetes mellitus (odds ratio [OR], 2.213; 95% confidence interval [CI], 1.403–3.612, P = 0.006), high–sensitivity C–reactive protein (OR, 1.143; 95% CI, 1.058–1.304, P = 0.012), microalbuminuria (albumin levels of 30 to 300 mg/g of creatinine) (OR, 2.124; 95% CI, 1.041–3.214, P = 0.018), and anemia (OR: 2.112; 95% CI 1.022–3.208, P = 0.028).
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