The complement C1qA enhances RIG-I mediated immune signaling

Immunology, 03/02/2012

The data show that ovexpression of C1qA upregulates RIG–I mediated activation of ISRE and NF–κB reporters and IFN–β transcription, but not IRF–3 and IKK–β mediated activation of ISRE and NF–κB promoter. In addition, C1qA can counteract with the function of C1q receptor gC1qR in RIG–I mediated signaling. The results reveal the important role of complement C1qA in innate immune response.

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