Cognitive Deficits in Machado-Joseph Disease Correlate with Hypoperfusion of Visual System Areas

The Cerebellum, 02/27/2012

A significant positive correlation was found between the Picture Completion test and perfusion of the left parahippocampal gyrus and basal ganglia in the patient group as well as a negative correlation between the TMT part A and bilateral thalamus perfusion. The visuospatial system is affected in patients with spinocerebellar ataxia type 3 (SCA3)/Machado–Joseph disease (MJD) and may be responsible for the cognitive deficits seen in this disease.

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