Cardiac Cell Therapies: The Next Generation

Cardiovascular Therapeutics, 10/15/2010

Accumulating evidence indicates that the postnatal mammalian heart retains a pool of tissue–specific progenitor cells and is also repopulated by cells from extracardiac sources. However, this intrinsic myocardial regeneration potential clearly needs to be augmented by either manipulation of the cell cycle of differentiated cells, activation of resident cardiac progenitor cells, and/or the transplantation of exogenous cells. This review summarizes the recent developments in cardiac regenerative medicine, many of which may find their way into the clinical setting in the foreseeable future.

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