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Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells

Neal CL et al. – This is the first report showing that Snail can negatively regulate maspin expression by directly repressing maspin promoter activity, leading to increased cell migration and invasion. Therefore, therapeutic targeting of Snail may be useful to re–induce expression of maspin tumor suppressor and prevent prostate cancer tumor progression. [more...]

BMC Cancer

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