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GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer

Li N et al. – Taken together, these findings reveal novel dynamic interactions between GRP78 and clusterin (CLU) under endoplasmic reticulum (ER) stress conditions that govern CLU trafficking and redistribution to the mitochondria, elucidating how GRP78 and CLU cooperatively promote survival during treatment stress in prostate cancer. [more...]

Oncogene

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