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Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

Sekar D et al. – The authors propose that CD69 expression on CD39+Treg cells enables them to interact with CD73–expressing CD8+T cells to generate adenosine, thereby suppressing cytotoxicity. These findings aid the understanding of how dying tumor cells limit antitumor immunity. [more...]

European Journal of Immunology

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