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Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

Koffie RM et al. – Together, the data suggest that apolipoprotein E4 is a co–factor that enhances the toxicity of oligomeric amyloid–β both by increasing its levels and directing it to synapses, providing a link between apolipoprotein E ε4 genotype and synapse loss, a major correlate of cognitive decline in Alzheimer’s disease. [more...]

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