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Paraneoplastic Isaacs Syndrome: A Case Series and Review of the Literature

Rana S et al. – The case series highlights the association of Isaacs' syndrome with a variety of neoplasms both malignant and benign. The report also underscores the fact that Isaacs' syndrome may be diagnosed several years before a neoplasm is discovered. In the cases, Isaacs' syndrome overlapped with other neuromuscular disorders, that is, myasthenia gravis in a patient with thymoma and chronic inflammatory demyelinating polyneuropathy in a patient with lymphoplasmacytic lymphoma with paraproteinemia. To the authors knowledge, this is the first report of an association between Isaacs' syndrome with lymphoplasmacytic lymphoma and a spinal cord hemangioblastoma. [more...]

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