mdlinx mdlinx

MDLinx E-mail Article

To email this article, enter your own "From Email" address, the recipient's "To Email" address, and click the "Send Email" button. You may send to up to 5 emails at a time.


* From Email: 
* To Email: 
To Email: 
To Email: 
To Email: 
To Email: 
Email Subject Line: 
Comments:

Novel insights into pathogenesis, diagnosis and treatment of antiphospholipid syndrome

Wijetilleka S et al. – Recent insights into the pathogenesis of antiphospholipid syndrome (APS) have unveiled novel areas for treatment intervention. Diagnostic criteria and recommendations have been revised and formulated to provide consensus and standardisation for diagnosis.

  • [beta]2GPI was recently implicated in the pathogenesis of thrombosis.
  • High titres of anti–[beta]2GPI antibodies are present in patients with triple positivity which highlight its importance.
  • Consensus guidelines have been published to standardise diagnostic assays and once implemented may yield more accurate diagnoses of APS.
  • An 'aPL score' has been formulated to improve the detection and outcomes of patients.
  • New oral anticoagulants, statins and concomitant therapy with warfarin and aspirin have been identified as potential novel therapeutic interventions for thrombotic APS.
  • Advances in the pathogenesis of obstetric APS have occurred, such as the concept of redefining the syndrome as inflammatory and clearer identification of the roles of complement, [beta]2GPI and annexin 5.
  • Independent risk factors for pregnancy failure have been recognised and when combined with clinical and laboratory features may improve patient outcomes.
  • Interventions involving adjusted doses of low molecular weight heparin in combination with aspirin have shown promising results from initial studies.

[more...]

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close