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Mechanistic correlations between two itch biomarkers, IL-31 cytokine and beta-endorphin neuropeptide, via STAT3/calcium axis in atopic dermatitis

Lee CH et al. – The authors concluded IL–31R activation in keratinocytes induced calcium influx and STAT3–dependent production of beta–endorphin. These results might contribute to an understanding of regulatory mechanisms underlying peripheral itch. [more...]

British Journal of Dermatology

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