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Diabetes and risk of esophageal and gastric adenocarcinomas

Jiang X et al. – The association between diabetes and risk of distal gastric adenocarcinomas (DGAs) was statistically significant only among patients for whom the authors interviewed their next of kin. The study further investigated the association between diabetes and adenocarcinomas of the esophagus and distal stomach.

Methods
  • This analysis included patients with esophageal adenocarcinoma (EA) (n=209), gastric cardia adenocarcinoma (GCA) (n=257) and DGA (n=382), and 1,309 control participants from a population-based case-control study conducted in Los Angeles County.
  • The study included non-Hispanic whites, African Americans, Hispanics and Asian Americans.
  • The association of diabetes with the three tumor types was estimated using polytomous logistic regression.
  • Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.

Results
  • Nine percent of control participants and 13% of the case patients reported a history of diabetes.
  • After adjustment for age, gender, race, birthplace, education, cigarette smoking status and body mass index, diabetes was associated with an increased risk of EA (OR, 1.48; 95% CI, 0.94-2.32; p=0.089) and DGA (OR, 1.47; 95% CI, 1.01-2.15; p=0.045), but was not associated with risk of GCA (OR, 0.96; 95% CI, 0.59-1.55; p=0.87).
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