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Association of Aurora-A (STK15) kinase polymorphisms with clinical outcome of esophageal cancer treated with preoperative chemoradiation

Pan JY et al. – The study shows that functional SNPs in the STK15 gene are associated with higher rate of recurrence, higher likelihood of chemoratiotherapy–resistance, shorter DFS, and shorter median survival time (MTS). Confirmation of the data and understanding the mechanisms through which STK15 functional SNPs mediate resistance to chemoradiotherapy are warranted. [more...]