MDLinx E-mail Article

To email this article, enter your own "From Email" address, the recipient's "To Email" address, and click the "Send Email" button. You may send to up to 5 emails at a time.


* From Email: 
* To Email: 
To Email: 
To Email: 
To Email: 
To Email: 
Email Subject Line: 
Comments:

Statins and Intracerebral Hemorrhage

Hackam DG et al. – Statin exposure following ischemic stroke was not associated with intracerebral hemorrhage (ICH).

Methods
  • Retrospective propensity–matched cohort study with accrual from July 1, 1994, to March 31, 2008.
  • A total of 17 872 patients aged 66 years and older who initiated statin therapy following acute ischemic stroke and were followed for a median of 4.2 years (interquartile range, 2.4–5.0 years).
  • To enhance causal inference, the conducted several tests of specificity to exclude healthy user bias in this sample.
  • Hospitalization or emergency department visit for ICH defined using validated diagnosis coding.

Results
  • Overall, 213 episodes of ICH occurred.
  • In the primary analysis comparing statin users with nonusers, the authors found no association between statins and ICH (hazard ratio = 0.87; 95% confidence interval, 0.65–1.17).
  • Subgroup and dose–response analyses yielded similar results.
  • In tests of specificity, statin therapy was not associated with bone mineral density testing, vitamin D or B12 screening, gastrointestinal endoscopy, or elective knee arthroplasty, suggesting that results were not due to healthy user bias or differences in quality of care.
[more...]