Internal Medicine News Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Evaluation and treatment of older patients with hypercholesterolemia: A clinical review JAMA, October 20, 2014    Clinical Article

2 Molecular findings among patients referred for clinical whole-exome sequencing JAMA, October 20, 2014    Evidence Based Medicine    Clinical Article

3 Detailed statistical analysis plan for the Danish Palliative Care Trial (DanPaCT) Full Text Trials, October 20, 2014    Evidence Based Medicine    Clinical Article

4 Clinical exome sequencing for genetic identification of rare Mendelian disorders JAMA, October 20, 2014    Evidence Based Medicine    Clinical Article

5 The effect of HIV infection on the host response to bacterial sepsis The Lancet Infectious Diseases, October 20, 2014    Review Article

6 The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on maternal diet and physical activity: the LIMIT randomised trial Full Text BMC Medicine, October 20, 2014    Evidence Based Medicine    Clinical Article

7 The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on neonatal health outcomes: the LIMIT randomised trial Full Text BMC Medicine, October 20, 2014    Evidence Based Medicine    Clinical Article

8 Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected The Journal of Infectious Diseases, October 20, 2014    Clinical Article

9 The salivary scavenger and agglutinin in early life: diverse roles in amniotic fluid and in the infant intestine The Journal of Immunology, October 20, 2014    Clinical Article

10 Regulatory T cells in central nervous system injury: a double-edged sword The Journal of Immunology, October 20, 2014    Clinical Article

11 Altered lipidome and antioxidative activity of small, dense HDL in normolipidemic rheumatoid arthritis: Relevance of inflammation Atherosclerosis, October 20, 2014    Clinical Article

12 The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by Dengue virus The Journal of Immunology, October 20, 2014    Clinical Article

13 TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity The Journal of Immunology, October 20, 2014    Clinical Article

14 Intact parathyroid hormone levels are associated with increased carotid intima media thickness in HIV infected patients Atherosclerosis, October 20, 2014    Clinical Article

15 HIV life cycle, innate immunity and autophagy in the central nervous system Current Opinion in HIV and AIDS, October 20, 2014    Review Article

16 Obesity and the obesity paradox in heart failure Canadian Journal of Cardiology, October 20, 2014    Review Article

17 Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment Brain, Behavior, and Immunity, October 20, 2014    Clinical Article

18 Elevated levels of IL-6 and IL-18 in manic and hypomanic states in rapid cycling bipolar disorder patients Brain, Behavior, and Immunity, October 20, 2014    Clinical Article

19 Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women Brain, Behavior, and Immunity, October 20, 2014    Clinical Article

20 Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation Immunology & Cell Biology, October 20, 2014    Clinical Article

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Clinical Pearls in Internal Medicine

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Highlights in Internal Medicine

Soluble TNF receptor II increased in MS patients

As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).


Other Topics in Internal Medicine

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