Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment Full Text
Saudi Journal of Gastroenterology, 07/18/2012
Rajendiran s et al. – The findings from this study indicate that treatment for both anemia and H. pylori infections is required for lowering the oxidative stress markers, which synergistically bring about an appropriate correction of anemia soon in these patients.Methods
- Protein carbonylation and total antioxidant status were estimated using colorimetric method.
- Hematologic parameters were evaluated using Sysmex-K-100 automated cell counter.
- In anemic H. pylori-infected patients, the protein carbonyls (PCOs) were significantly increased, whereas the total antioxidant status, iron, hemoglobin, and ferritin levels were significantly decreased compared with the controls.
- In Group I, while the PCOs level decreased significantly, there was a significant increase in the total antioxidant status, iron, hemoglobin, and ferritin levels after 1 month.
- No significant alterations were noted in the levels of PCOs, total antioxidant status, iron, hemoglobin, or ferritin in Group II patients after 1 month of the treatment.