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Role of Chlamydia trachomatis in Miscarriage Full Text
Emerging Infectious Diseases, 08/29/2011
Baud D et al. – Associations between miscarriage and serologic/molecular evidence of Chlamydia trachomatis infection support its role in miscarriage.
Methods- Serum, cervicovaginal swab specimens, and placental samples were prospectively collected from 386 women with and without miscarriage.
- Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018).
- Association between C. trachomatis–positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1–4.9).
- C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026).
- Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested.
