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Infection of human enteroendocrine cells with Chlamydia trachomatis: a possible model for pathogenesis in irritable bowel syndrome
Neurogastroenterology and Motility, 08/23/2011
Dlugosz A et al. – In line with the microscopical findings, the authors found a significant down–regulation of the gene coding for the vesicular monoamine transporter (VMAT1) in infected compared with non–infected enteroendocrine cellsenteroendocrine cells(EEC). Altered protein distributions together with down–regulation of VMAT1 suggest that chlamydial infection may influence vesicular transport. It is therefore possible that such an infection in vivo could lead to disturbances in the regulation of gut functions.