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Novel Trichomonacidal Spermicides
Antimicrobial Agents and Chemotherapy, 08/23/2011
Jain A et al. – The authors report here the in vitro activities, structure–activity relationships, and safety profiles of these spermicidal antitrichomonas agents, the most promising of which was more effective than N–9 (the OTC spermicide) in inactivating human sperm and more efficacious than metronidazole in killing Trichomonas vaginalis (including metronidazole–resistant strain). It also significantly reduced the available free thiols on human sperm and inhibited the cytoadherence of Trichomonas on HeLa cells. Experimentally in vitro, the new compounds appeared to be safer than N–9 for vaginal use.