Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment Full Text
BMC Microbiology, 08/17/2011
Murphy TF et al. – The Haemophilus influenzae genome contains a single urease operon that mediates urease expression and that is present in all clinical isolates tested. Nitrogen availability is a determinant of urease expression. H. influenzae expresses urease during human respiratory tract infection and urease is a target of the human antibody response. Expression of urease enhances viability in an acid environment. Taken together, these observations suggest that urease is important for survival and replication of H. influenzae in the human respiratory tract.






