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Norovirus Gastroenteritis Successfully Treated with Nitazoxanide
Journal of Infection, 08/12/2011
Siddiq DM et al. – Infectious diarrhea is a common occurrence in the immunosuppressed population. The authors present a 43–year–old individual with large–volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy–proven cutaneous and pulmonary graft–versus–host disease. Therapeutic options such as intravenous immunoglobulin or reduction of immunosuppressants were not a feasible choice. A prompt clinical cure was achieved with nitazoxanide, a broad–spectrum antimicrobial agent. Nitazoxanide may be a safe therapeutic alternative, in which a reduction in immunosuppression may not be a viable option.
