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Extent of antigenic cross-reactivity among highly pathogenic H5N1 influenza viruses
Journal of Clinical Microbiology, 08/12/2011
Ducatez MF et al. – Hemagglutination inhibition (HI) with horse red blood cells seems to be the assay of choice for H5N1 diagnostics. While clade 2.2 antigens were able to detect antibodies raised to most of the tested H5N1 viruses (and clade 2.2–specific antisera detected most of the H5N1 antigens) ancestral strain A exhibited the widest reactivity pattern and hence was the best candidate diagnostic reagent for broad detection of H5N1 strains.
