Vancomycin Treatment of Infective Endocarditis Is Linked with Recently Acquired Obesity
PLOS ONE, 02/19/2010
Thuny F et al. – A major and significant weight gain can occur after a six–week intravenous treatment by vancomycin plus gentamycin for IE with a risk of obesity, especially in males older than 65 who have not undergone surgery. The authors speculate on the role of the gut colonization by Lactobacillus sp, a microorganism intrinsically resistant to vancomycin, used as a growth promoter in animals, and found at a high concentration in the feces of obese patients. Thus, nutritional programs and weight follow–up should be utilized in patients under such treatment.