Investigation of the proteolytic functions of an expanded cercarial elastase gene family in schistosoma mansoni
PLoS Neglected Tropical Diseases, 04/04/2012
Ingram JR et al. – The expansion of the cercarial gene family in S. mansoni is likely to be an example of gene dosage. In addition to its critical role in human skin penetration, data presented here suggests a novel role for the protease in egress from the intermediate snail host. This study demonstrates how enzyme activity–based analysis complements genomic and proteomic studies, and is key in elucidating proteolytic function.