Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH
Iida H et al. – In H. pylori –negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.
- Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study.
- Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride).
- Each administration was separated by a 7-days washout period.
- The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).